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download pdf Neurosurgery, 2017
Congress of Neurological Surgeons (CNS) and the AANS/CNS Tumor Section
Joint Guidelines Committee of the American Association of Neurological Surgeons (AANS) and the Congress of Neurological Surgeons (CNS)
Jeffrey J. Olson, MD11, Steven N. Kalkanis, MD2, Timothy C. Ryken, MD3
1. Department of Neurosurgery, Emory University School of Medicine, Atlanta, Georgia, USA
2. Department of Neurosurgery, Henry Ford Health System, Detroit, Michigan, USA
3. Department of Neurosurgery, Dartmouth University School of Medicine, Hanover, New Hampshire, USA
Jeffrey J. Olson, MD Department of Neurosurgery Emory University School of Medicine Atlanta, Georgia Email: firstname.lastname@example.org
Vestibular schwannomas (VS) are uncommon lesions that are a substantial challenge to the neurosurgeons and otologists who undertake their clinical management. The majority of the population may live their entire lives without ever hearing the term VS, let alone knowing an affected individual. To provide context, only approximately 3300 VSs are diagnosed per year in the United States, indicating an incidence of 1.09 per 100,000 people. This incidence increases with age, peaking in the 65- to 74-year-old age group. The incidence is higher in Asian Pacific Islanders and lower in African Americans and Hispanics.1 Based on a 2010 study, the estimated prevalence (1:60,000) is higher than previously believed.2 An important subset of these individuals also have neurofibromatosis type 2 (NF2), potentially allowing a basis on which to understand the underlying molecular genesis of these lesions.2-5
The treatment goals for any cranial neoplasm, whether benign or malignant, are either disease cure or meaningful control, along with maintenance of neurologic function and quality of life. The presence of a VS has been associated with a decline in health-related quality of life measurement, regardless of the management chosen, including observation alone. Interestingly, microsurgical management has been associated with the greatest decrement in health-related quality of life measurements. Patients who underwent microsurgery had statistically significantly worse outcomes in their Pennsylvania Acoustic Neuroma Quality of Life total score by 8% to 11% (P < .023) compared with those treated with stereotactic radiosurgery or observation, respectively. The scores for those undergoing microsurgery were significantly less (P < .001) than those treated with stereotactic radiosurgery or observation in the subdomains of facial function (13–14%), balance (10–19%), and pain (19–30%). These findings must be balanced against more patients with unequivocal tumor growth or intractable symptoms having undergone microsurgical intervention.6 This may not be surprising to many surgeons, and the history of the surgical management of these lesions is replete with valiant attempts at improvement.
One of the earliest documented attempt at surgical resection of a VS via a unilateral suboccipital approach was noted by Annandale in 1895.7 Early surgery in the cerebellopontine angle region has been limited by technical ability, equipment, anesthesia, and late presentation. Even Cushing referred to this location as the “bloody angle,” although he substantially improved outcomes in the 1920s compared with his surgical predecessors.8,9 By the 1940s, Dandy had reduced the mortality rate to just over 10%, advocating total resection over intracapsular removal as advocated by Cushing.10-13 Middle fossa approaches for various syndromes of the vestibulocochlear complex have been reported since at least 1904 when Parry described the approach, attempting surgical management for tinnitus.14 The first translabyrinthine VS resection was reported as part of a 2-stage procedure by Franciscus H. Quix in 1912.15 This approach was popularized by William House, and along with the retrosigmoid approach, have become the mainstay of surgical management of VS.16
In the modern era, the development of alternatives to surgical management have become important considerations in the discussion of VS therapy. For example, the original description of stereotactic radiosurgery (Gamma Knife) by Leksell17,18 did not specifically envision treatment of VS; however, these lesions have become an appealing target for this minimally invasive option. In addition, although generally applied to malignant disease, bevacizumab has been suggested as a possible therapy in select cases of NF2, adding the consideration of medical therapy to the discussion of VS management options.19
Outcomes remain imperfect, and improvements in these therapeutic steps are necessary. This is as true for surgical management as it is for radiotherapy approaches.20-22 Although much information has been garnered from current large retrospective clinical data series, it appears we have maximized the information to be gained by simply increasing the numbers of patients treated in the same fashion and adding to the duration of follow-up.
The population of patients with VSs is a heterogeneous one with differences in age at presentation, baseline hearing and neurologic status, overall health, tumor size and location, and patient preferences and biases. Outcome is not a singular entity either and can be measured by extent of resection, postoperative hearing and neurologic status, period of disease control, and type of therapy needed for management of recurrence. A matrix of decision nodes for an algorithm or decision tree addressing these items in a meaningful fashion is not achievable. First, because of its obvious complexity and secondarily because of the class III or lack of data addressing many of those decisions. A useful starting point to improving the current knowledgebase is to define the benchmarks of our current knowledge regarding VS management using evidence-based techniques in order to allow meaningful points of departure for future scientific and clinical research.
Recognizing the important health impacts of VSs, along with the lack of consensus among various treatment options, the Joint Tumor Section of the American Association of Neurological Surgeons (AANS) and the Congress of Neurological Surgeons (CNS) recommended that evidence-based guidelines be developed as a top priority, for the diagnosis, management, and treatment of VS patients. The objectives of these guidelines are to establish the best evidence-based management of VSs, including initial otologic evaluation, imaging diagnosis, use of surgical techniques, assessment of tumor pathology, and the administration of radiation therapy. Because management of these tumors remains imperfect, it was also recommended that information on promising emerging therapies be assessed in the same manner to determine the possible application of these findings.
Having identified the topical objectives, the Guidelines Committee of the Joint Tumor Section recruited experts in the field from each of the parent organizations as lead writers of each section. These writers, in turn, recruited experts in non-neurosurgical specialties relevant to the field of management and therapy chosen. Writers were provided training on the CNS method of guideline development as used in this guideline set, using stepwise written instructions and then providing direct guidance as needed for each writer. The senior authors and CNS Guidelines Manager then assisted with the development of a step-by-step process to confirm that the methods were followed as the literature was collected and assessed and the documents developed. When writers were approached and preliminarily agreed to participate, they were asked to complete a formal conflict of interest questionnaire confirming the appropriateness of their participation. Writers also agreed to report any new conflicts of interest that might develop during the writing process. In this manner a multidisciplinary panel of writers referred to as the Vestibular Schwannoma Guidelines Task Force was assembled (Table 1), with significant administrative, logistical, and analytical support from the CNS Guidelines Committee. The method of this evidence-based clinical practice parameter has been written in a manner to be as transparent as possible using published assessment criteria.23,24
Having identified writing groups for each topic, the members designed questions to allow assessment of the literature in a manner that would provide guidance for the management of VSs. These questions are presented at the beginning of each of the 9 guideline chapters spanning the topics of otologic assessment, imaging assessment, surgical resection, tumor evaluation by standard neuropathology and molecular techniques, radiation therapy, and emerging concepts and therapies. The questions developed for each section are summarized in Table 2.
A wide-ranging literature search strategy was undertaken to identify all citations relevant to the management of VSs. The PubMed and Embase electronic databases were searched from 1990 through 2014, with additional data being gleaned from the Cochrane Central Register of Controlled Trials and Web of Science. Other specialized databases considered are noted in the methods of the individual topic sections. The writing groups used the databases that provided the greatest breadth of nonoverlapping citations that were pertinent to answering the questions they had developed. Some databases may provide more information on therapy while others may provide more information on prognosis and diagnostic techniques, allowing the authors to make maximize the efficiency and value of their searches (Table 3). In addition, important articles from before this interval were reviewed and included if deemed to be critical evidence by the writing group. Such historic articles were subject to the same scrutiny for bias as manuscripts in the interval from 1990 through 2014 and those weaknesses pointed out when they were used. The search strategies used a combination of controlled vocabulary and text words. The specifics of the searches for a given topic are outlined in each respective guideline section. Reference lists of the publications chosen for full-text review were also screened for potentially relevant studies.
The searches of the bibliographic databases identified possibly relevant citations for a given topic, and often these were large in number. The eligibility (inclusion/exclusion) criteria to screen the citations for each of the questions were determined ahead of time for each section by the respective writing group. These are documented in the individual clinical practice guideline sections in this series to assist the reader in understanding the development process. At least 2 authors evaluated the titles and abstracts using the inclusion and exclusion criteria with broad interpretation of the criteria being used initially, so as to maximize the likelihood of capturing pertinent information. Cases of disagreement about pertinence were resolved by a third author when needed. The full-text articles of the selected abstracts were then collected and the same process of applying the eligibility criteria was carried out again with the more in depth information available. Articles that met the eligibility criteria were grouped according to the questions they addressed and used to create the evidence tables and scientific foundation sections. Reasons for exclusion for papers were also documented to be able to discuss pertinent problem citations in the scientific foundation as needed.
Studies that met the eligibility criteria were subject to more detailed scrutiny and had their data extracted by 1 reviewer and the extracted information was checked by 1 or more other reviewers. Evidence and summary tables, reporting the extracted study information and evidence classification, were generated for all the included studies for each of the questions. Evidence tables were created with the most recent data first and subsequent listings in retrograde chronological order. The table headings consisted of first author name and year, followed by a brief study description, chosen data class, and conclusion. The authors were directed to craft the data in the tables in a succinct and fact-filled manner to allow for rapid understanding of the literature entry by the readership. The literature in the evidence tables was expanded upon in the Results section of each guideline article to emphasize important points supporting its classification and contribution to recommendations. The method by which this was accomplished is expanded upon in the Joint Guideline Committee (JGC) Guideline Development Methodology document. Internal drafts of the tables and manuscripts were developed by sharing them between writers electronically, by telephone, and in face-to-face meetings. Summary and conclusion statements were included for each section, with comments on key issues for future investigation being added where pertinent.
No question resulted in a collection of studies that warranted a meta-analysis.
The evidence classifications were then used to create recommendations, the strength of which were graded according to the JGC Guideline Development Methodology (Tables 4–7). The class of evidence assigned to each study was based on study design (ie, class I, II, or III). The strength of the recommendations made (ie, level 1, 2, or 3) was directly linked to the evidence classification and took into account aspects of study quality and whether or not the plan was accomplished, not just study design. Specifically, the level of a recommendation made could be decreased, based on consensus input by the writing group, if there were methodological concerns regarding the studies that provided evidence for that particular recommendation.
As mentioned above, multidisciplinary writing groups were created for each section based on author expertise to address each of the disciplines and particular areas of therapy selected for these clinical guidelines. Each group was involved with literature selection, creation and editing of the evidence tables, and scientific foundations for their specific section and discipline. Using this information, the writing groups then drafted the recommendations in answer to the questions formulated at the beginning of the process, culminating in the clinical practice guideline for their respective discipline. The draft guidelines were then circulated to the entire clinical guideline panel to allow for multidisciplinary feedback, discussion, and ultimately approval.
The completed evidence-based clinical practice guidelines for the management of VSs were presented to the JGC of the AANS/CNS for review. The reviewers for the JGC were vetted by Neurosurgery for suitability and expertise to serve as reviewers for the purposes of publication in that journal also. The final product was then approved and endorsed by the executive committees of both the AANS and CNS before publication in Neurosurgery.
Development of this set of evidence-based clinical practice guidelines was editorially independent from the funding agencies. The funding agencies (the CNS Executive Committee and the AANS/CNS Joint Tumor Section Executive Committee) were permitted to review these guidelines only after the JGC had completed its extensive review, critique, and ultimate approval process. The funding groups then were limited to whether or not to endorse or reject this body of work, but substantive changes were not allowed. Figure 1 provides an outline of the key steps in the process of developing these clinical practice guidelines.
This series of guidelines was constructed to assess the most current and clinically relevant evidence for management of VSs to set a benchmark while also highlighting important key areas for future research. Only by designing future investigations in a high-quality manner that recognizes and overcomes previous weaknesses noted in these guidelines will advancement toward a remedy of this disease be achieved. Secondarily, the suggestions provided are set forth for conscientious use by the practicing physician who must consider all of the unique individual conditions in the therapy of a given person during his or her illness. The application of published guidelines information is an activity that results in strong and often polarized opinions. The guidelines presented in this current project are not meant to resolve these issues, and it is unlikely that any could accomplish such a goal. Fortunately, new research is constantly underway, and these guidelines are meant to be improved upon as this new evidence matures and is published. To that point, the data analyzed for this set of guidelines have been collected through 2014. This literature will be evaluated at least every 5 years and the guidelines will be reviewed and updated accordingly to ensure its continued validity and currency.
The Vestibular Schwannoma Guidelines Task Force members reported all possible conflicts of interest (COIs) before beginning work on the guideline, using the COI disclosure form of the JGC, including potential COIs that are unrelated to the topic of the guideline. The CNS Guidelines Committee and Guideline Task Force Chair reviewed the disclosures and either approved or disapproved the nomination. The CNS Guidelines Committee and Guideline Task Force Chair are given latitude to approve nominations of Task Force Members with possible conflicts and address this by restricting the writing and reviewing privileges of that person to topics unrelated to the possible COIs (Table 8).
These evidence-based clinical practice guidelines were funded exclusively by the CNS and the Section on Tumors of the Congress of Neurological Surgeons and the AANS, which received no funding from outside commercial sources to support the development of this document.
This clinical systematic review and evidence-based guideline was developed by a physician volunteer task force as an educational tool that reflects the current state of knowledge at the time of completion. Each chapter is designed to provide an accurate review of the subject matter covered. This guideline is disseminated with the understanding that the recommendations by the authors and consultants who have collaborated in their development are not meant to replace the individualized care and treatment advice from a patient's physician(s). If medical advice or assistance is required, the services of a competent physician should be sought. The proposals contained in these guidelines may not be suitable for use in all circumstances. The choice to implement any particular recommendation contained in these guidelines must be made by a managing physician in light of the situation in each particular patient and on the basis of existing resources.
The guidelines task force would like to acknowledge the CNS Guidelines Committee for their contributions throughout the development of the guideline, the AANS/Congress of Neurological Surgeons Joint Guidelines Committee for their review, comments, and suggestions throughout peer review, as well as the contributions of Trish Rehring, MPH, CHES, Senior Manager of Clinical Practice Guidelines for the CNS, and Mary Bodach, MLIS, for assistance with the literature searches. Throughout the review process the reviewers and authors were blinded from one another. At this time the guidelines task force would like to acknowledge the following individual peer reviewers for their contributions: Sepideh Amin-Hanjani, MD, D. Ryan Ormond, MD, Andrew P. Carlson, MD, Kimon Bekelis, MD, Stacey Quintero Wolfe, MD, Chad W. Washington, MD, Cheerag Dipakkumar Upadhyaya, MD, and Mateo Ziu, MD.
Table 1. Guideline Author
The Greater Houston Neurosurgery Center,
Department of Neurosurgery and Brain Repair, College of Medicine,
University of South Florida,
Carolina Neurosurgery & Spine Associates,
Department of Neurosurgery
Brigham and Women’s Hospital,
Harvard Medical School,
Department of Radiation Oncology,
Levine Cancer Institute,
Departments of Otorhinolaryngology and Neurosurgery,
Mayo Clinic School of Medicine,
Division of Otolaryngology-Head and Neck Surgery,
Department of Radiology (Neuroradiology)
Icahn School of Medicine at Mount Sinai
Department of Pathology,
Isabelle M. Germano, MD
Department of Neurosurgery,
Icahn School of Medicine at Mount Sinai,
Mount Sinai Beth Israel,
Henry Ford Health System,
Department of Neurologic Surgery,
Emory University School of Medicine,
Division of Neuroradiology,
Mayo Clinic, School of Medicine,
Jonathan Parish, MD
Carolinas Medical Center,
Department of Otorhinolaryngology
Department of Neurological Surgery,
University of Virginia,
University of Oklahoma,
Bobby R. Alford Department of Otolaryngology-Head and Neck Surgery,
Baylor College of Medicine,
Departments of Oncology and Neurology,
Department of Otolaryngology-Head and Neck Surgery,
Table 2. Questions addressed in this guideline
Audiometric Methods in the Screening and Diagnosis of Vestibular Schwannomas
Hearing Preservation in Vestibular Schwannomas
The Role of Imaging in the Diagnosis and Management of Vestibular Schwannomas
The Role of Surgery in the Management of Vestibular Schwannomas
Cranial Nerve Monitoring in Management of Vestibular Schwannomas
Pathology Techniques in the Diagnosis and Management of Vestibular Schwannomas
Pathology Techniques for Diagnosis
Pathology Techniques for Assessment of Prognosis
The Role of Radiation Therapy in the Management of Vestibular Schwannomas
Emerging Modalities in the Diagnosis and Management of Vestibular Schwannomas
AAO-HNS, American Academy of Otolaryngology-Head and Neck Surgery; CISS, constructive interference steady state; DTI, diffusion tensor imaging; FIESTA, fast imaging employing steady-state acquisition; FN, facial nerve; GR, Gardner–Robertson hearing classification; IAC, internal auditory canal; LINAC, linear accelerator; MRI, magnetic resonance imaging; NF2, neurofibromatosis type 2; SRS, stereotactic radiosurgery; VS, vestibular schwannoma.
Table 3. Databases searched by section
Table 4. American Association of Neurological Surgeons/Congress of Neurological Surgeons classification of evidence on therapeutic effectiveness and levels of recommendation
Table 5. American Association of Neurological Surgeons/Congress of Neurological Surgeons classification of evidence on diagnosis and levels of recommendation
Class I evidence
Class II evidence
Class III evidence
Table 6. American Association of Neurological Surgeons/Congress of Neurological Surgeons classification of evidence on clinical assessment and levels of recommendation
Table 7. American Association of Neurological Surgeons/Congress of Neurological Surgeons classification of evidence on prognosis and levels of recommendation
To evaluate papers addressing prognosis, 5 technical criteria are applied:
Table 8. Conflict of interest disclosures
NCI, National Cancer Institute; NIH, National Institutes of Health.
Figure 1. An outline of the key steps in the process of developing these clinical practice guidelines. AANS, American Association of Neurological Surgeons; CNS, Congress of Neurological Surgeons; JGC, Joint Guidelines Committee.
© Congress of Neurological Surgeons
Source: Neurosurgery, February 2018
2. Otologic and Audiologic Screening for Patients with Vestibular Schwannomas